Regional trade agreements depend on the level of commitment and agreement between member states. A trade agreement signed between more than two parties (usually neighbouring or in the same region) is considered multilateral. They face the main obstacles – to content negotiation and implementation. The more countries involved, the more difficult it is to achieve mutual satisfaction. Once this type of trade agreement is governed, it will become a very powerful agreement. The larger the GDP of the signatories, the greater the impact on other global trade relations. The largest multilateral trade agreement is the North American Free Trade Agreement between the United States, Canada and Mexico.  Member States benefit from trade agreements, notably in the form of increased employment opportunities, lower unemployment and increased market opportunities. Since trade agreements generally come with investment guarantees, investors who wish to invest in developing countries are protected from political risks. The most favoured nation clause prevents one of the parties to the current agreement from continuing to remove barriers to another country. For example, in exchange for reciprocal concessions, Country A could agree to reduce tariffs on certain products from Country B. In the absence of a clause of the most favoured nation, Country A could still reduce tariffs on the same goods from Country C in exchange for other concessions.
As a result, consumers in Country A could purchase the products in question at a cheaper price in Country C because of the tariff difference, while Country B would get nothing for its concessions. The status of the most favoured nation means that A is required to extend the lowest existing tariff to certain products to all its trading partners enjoying such status. If A later accepts a lower rate with C, B automatically gets the same lower rate. Reciprocity is a necessary feature of any agreement. If each required party does not win by the agreement as a whole, there is no incentive to approve it. If an agreement is reached, it can be assumed that each contracting party expects to win at least as much as it loses. For example, Country A, in exchange for removing barriers to country B products, which benefit A consumers and B producers, will insist that Country B reduce barriers to country A products and thus benefit country A producers and perhaps B consumers. Two countries participate in bilateral agreements. Both countries agree to relax trade restrictions to expand business opportunities between them. They reduce tariffs and give themselves privileged trade status.
In general, the point of friction is important national industries that are protected or subsidized by the state. In most countries, they are active in the automotive, oil and food industries. The Obama administration negotiated with the European Union the world`s largest bilateral agreement, the Transatlantic Trade and Investment Partnership. In most modern economies, there are many coalitions of interested groups and the diversity of possible unilateral barriers is important.